Solid Dispersion
The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic matrix and hydrophobic drug. When the solid dispersion is exposed to aqueous media, the carrier dissolves the drug and releases as fine colloidal particles. The result is enhanced surface area, which produces higher dissolution rate and bioavailability is greatly increased of poorly water-soluble drugs.
- To enhance the absorption of drug.
- To obtain a homogeneous distribution of a small amount of drug in solid state.
- To dispense liquid or gaseous compounds.
- To formulate a fast release priming dose in a sustained release dosage form.
- To formulate sustained release preparation of soluble drugs by dispersing the drug in poorly soluble or insoluble carrier.
- To reduce side effects, the binding ability of drugs (for example to the erythrocyte membrane) is decreased by making its inclusion complex.
- Particles with enhanced wettability & solubility.
- Particles with higher porosity & higher dissolution.
- Drugs in amorphous state, higher drug release.